Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH.

Kimura, Masaki; Iguchi, Takuma; Iwasawa, Kentaro; Dunn, Andrew; Thompson, Wendy L; Yoneyama, Yosuke; Chaturvedi, Praneet; Zorn, Aaron M; Wintzinger, Michelle; Quattrocelli, Mattia; Watanabe-Chailland, Miki; Zhu, Gaohui; Fujimoto, Masanobu; Kumbaji, Meenasri; Kodaka, Asuka; Gindin, Yevgeniy; Chung, Chuhan; Myers, Robert P; Subramanian, G Mani; Hwa, Vivian; Takebe, Takanori.

Cell ; 185(22): 4216-4232.e16, 2022 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-36240780

2.

IL-31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH.

Xu, Jun; Wang, Ya; Khoshdeli, Mina; Peach, Matt; Chuang, Jen-Chieh; Lin, Julie; Tsai, Wen-Wei; Mahadevan, Sangeetha; Minto, Wesley; Diehl, Lauri; Gupta, Ruchi; Trauner, Michael; Patel, Keyur; Noureddin, Mazen; Kowdley, Kris V; Gulamhusein, Aliya; Bowlus, Christopher L; Huss, Ryan S; Myers, Robert P; Chung, Chuhan; Billin, Andrew N.

Hepatology ; 77(1): 20-32, 2023 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-35686937

3.

Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis.

Loomba, Rohit; Huang, Daniel Q; Sanyal, Arun J; Anstee, Quentin Mark; Trauner, Michael; Lawitz, Eric J; Ding, Dora; Ma, Lily; Jia, Catherine; Billin, Andrew; Huss, Ryan S; Chung, Chuhan; Goodman, Zachary; Wong, Vincent Wai-Sun; Okanoue, Takeshi; Romero-Gómez, Manuel; Abdelmalek, Manal F; Muir, Andrew; Afdhal, Nezam; Bosch, Jaime; Harrison, Stephen; Younossi, Zobair M; Myers, Robert P.

Gut ; 72(3): 581-589, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36750244

4.

Acetyl-CoA carboxylase inhibitor increases LDL-apoB production rate in NASH with cirrhosis: prevention by fenofibrate.

Dandan, Mohamad; Han, Julia; Mann, Sabrina; Kim, Rachael; Li, Kelvin; Mohammed, Hussein; Chuang, Jen-Chieh; Zhu, Kaiyi; Billin, Andrew N; Huss, Ryan S; Chung, Chuhan; Myers, Robert P; Hellerstein, Marc.

J Lipid Res ; 64(3): 100339, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36737040

5.

Fenofibrate Mitigates Hypertriglyceridemia in Nonalcoholic Steatohepatitis Patients Treated With Cilofexor/Firsocostat.

Lawitz, Eric J; Bhandari, Bal Raj; Ruane, Peter J; Kohli, Anita; Harting, Eliza; Ding, Dora; Chuang, Jen-Chieh; Huss, Ryan S; Chung, Chuhan; Myers, Robert P; Loomba, Rohit.

Clin Gastroenterol Hepatol ; 21(1): 143-152.e3, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-34999207

6.

Safety and Sustained Efficacy of the Farnesoid X Receptor (FXR) Agonist Cilofexor Over a 96-Week Open-label Extension in Patients With PSC.

Trauner, Michael; Bowlus, Christopher L; Gulamhusein, Aliya; Hameed, Bilal; Caldwell, Stephen H; Shiffman, Mitchell L; Landis, Charles; Muir, Andrew J; Billin, Andrew; Xu, Jun; Liu, Xiangyu; Lu, Xiaomin; Chung, Chuhan; Myers, Robert P; Kowdley, Kris V.

Clin Gastroenterol Hepatol ; 21(6): 1552-1560.e2, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-35934287

7.

Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis.

Sanyal, Arun J; Anstee, Quentin M; Trauner, Michael; Lawitz, Eric J; Abdelmalek, Manal F; Ding, Dora; Han, Ling; Jia, Catherine; Huss, Ryan S; Chung, Chuhan; Wong, Vincent Wai-Sun; Okanoue, Takeshi; Romero-Gomez, Manuel; Muir, Andrew J; Afdhal, Nezam H; Bosch, Jaime; Goodman, Zachary; Harrison, Stephen A; Younossi, Zobair M; Myers, Robert P.

Hepatology ; 75(5): 1235-1246, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-34662449

8.

PRIMIS: design of a pivotal, randomized, phase 3 study evaluating the safety and efficacy of the nonsteroidal farnesoid X receptor agonist cilofexor in noncirrhotic patients with primary sclerosing cholangitis.

Trauner, Michael; Chung, Chuhan; Sterling, Kate; Liu, Xiangyu; Lu, Xiaomin; Xu, Jun; Tempany-Afdhal, Clare; Goodman, Zachary D; Färkkilä, Martti; Tanaka, Atsushi; Trivedi, Palak; Kowdley, Kris V; Bowlus, Christopher L; Levy, Cynthia; Myers, Robert P.

BMC Gastroenterol ; 23(1): 75, 2023 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-36922785

9.

Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury.

Liu, Xiaoying; Khalafalla, Mahmoud; Chung, Chuhan; Gindin, Yevgeniy; Hubchak, Susan; LeCuyer, Brian; Kriegermeier, Alyssa; Zhang, Danny; Qiu, Wei; Ding, Xianzhong; Fang, Deyu; Green, Richard.

J Lipid Res ; 63(11): 100289, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-36162519

10.

Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients.

Lawitz, Eric J; Li, Kelvin W; Nyangau, Edna; Field, Tyler John; Chuang, Jen-Chieh; Billin, Andrew; Wang, Lulu; Wang, Ya; Huss, Ryan S; Chung, Chuhan; Subramanian, G Mani; Myers, Robert P; Hellerstein, Marc K.

J Lipid Res ; 63(9): 100250, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35835205

11.

A Machine Learning Approach to Liver Histological Evaluation Predicts Clinically Significant Portal Hypertension in NASH Cirrhosis.

Bosch, Jaime; Chung, Chuhan; Carrasco-Zevallos, Oscar M; Harrison, Stephen A; Abdelmalek, Manal F; Shiffman, Mitchell L; Rockey, Don C; Shanis, Zahil; Juyal, Dinkar; Pokkalla, Harsha; Le, Quang Huy; Resnick, Murray; Montalto, Michael; Beck, Andrew H; Wapinski, Ilan; Han, Ling; Jia, Catherine; Goodman, Zachary; Afdhal, Nezam; Myers, Robert P; Sanyal, Arun J.

Hepatology ; 74(6): 3146-3160, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34333790

12.

A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis.

Gindin, Yevgeniy; Chung, Chuhan; Jiang, Zhaoshi; Zhou, Jing Zhu; Xu, Jun; Billin, Andrew N; Myers, Robert P; Goodman, Zachary; Landi, Abdolamir; Houghton, Michael; Green, Richard M; Levy, Cynthia; Kowdley, Kris V; Bowlus, Christopher L; Muir, Andrew J; Trauner, Michael.

Hepatology ; 73(3): 1105-1116, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-32745270

13.

A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH.

Taylor-Weiner, Amaro; Pokkalla, Harsha; Han, Ling; Jia, Catherine; Huss, Ryan; Chung, Chuhan; Elliott, Hunter; Glass, Benjamin; Pethia, Kishalve; Carrasco-Zevallos, Oscar; Shukla, Chinmay; Khettry, Urmila; Najarian, Robert; Taliano, Ross; Subramanian, G Mani; Myers, Robert P; Wapinski, Ilan; Khosla, Aditya; Resnick, Murray; Montalto, Michael C; Anstee, Quentin M; Wong, Vincent Wai-Sun; Trauner, Michael; Lawitz, Eric J; Harrison, Stephen A; Okanoue, Takeshi; Romero-Gomez, Manuel; Goodman, Zachary; Loomba, Rohit; Beck, Andrew H; Younossi, Zobair M.

Hepatology ; 74(1): 133-147, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-33570776

14.

Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH.

Loomba, Rohit; Noureddin, Mazen; Kowdley, Kris V; Kohli, Anita; Sheikh, Aasim; Neff, Guy; Bhandari, Bal Raj; Gunn, Nadege; Caldwell, Stephen H; Goodman, Zachary; Wapinski, Ilan; Resnick, Murray; Beck, Andrew H; Ding, Dora; Jia, Catherine; Chuang, Jen-Chieh; Huss, Ryan S; Chung, Chuhan; Subramanian, G Mani; Myers, Robert P; Patel, Keyur; Borg, Brian B; Ghalib, Reem; Kabler, Heidi; Poulos, John; Younes, Ziad; Elkhashab, Magdy; Hassanein, Tarek; Iyer, Rajalakshmi; Ruane, Peter; Shiffman, Mitchell L; Strasser, Simone; Wong, Vincent Wai-Sun; Alkhouri, Naim.

Hepatology ; 73(2): 625-643, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33169409

15.

Inter- and Intra-individual Variation, and Limited Prognostic Utility, of Serum Alkaline Phosphatase in a Trial of Patients With Primary Sclerosing Cholangitis.

Trivedi, Palak J; Muir, Andrew J; Levy, Cynthia; Bowlus, Christopher L; Manns, Michael P; Lu, Xiaomin; Crans, Gerald; Chung, Chuhan; Subramanian, G Mani; Myers, Robert P; Goodman, Zachary; Chalasani, Naga; Vierling, John M; Guha, Indra Neil; Hirschfield, Gideon M.

Clin Gastroenterol Hepatol ; 19(6): 1248-1257, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-32707342

16.

Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial.

Patel, Keyur; Harrison, Stephen A; Elkhashab, Magdy; Trotter, James F; Herring, Robert; Rojter, Sergio E; Kayali, Zeid; Wong, Vincent Wai-Sun; Greenbloom, Susan; Jayakumar, Saumya; Shiffman, Mitchell L; Freilich, Bradley; Lawitz, Eric J; Gane, Edward J; Harting, Eliza; Xu, Jun; Billin, Andrew N; Chung, Chuhan; Djedjos, C Stephen; Subramanian, G Mani; Myers, Robert P; Middleton, Michael S; Rinella, Mary; Noureddin, Mazen.

Hepatology ; 72(1): 58-71, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32115759

17.

The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis.

Trauner, Michael; Gulamhusein, Aliya; Hameed, Bilal; Caldwell, Stephen; Shiffman, Mitchell L; Landis, Charles; Eksteen, Bertus; Agarwal, Kosh; Muir, Andrew; Rushbrook, Simon; Lu, Xiaomin; Xu, Jun; Chuang, Jen-Chieh; Billin, Andrew N; Li, Georgia; Chung, Chuhan; Subramanian, G Mani; Myers, Robert P; Bowlus, Christopher L; Kowdley, Kris V.

Hepatology ; 70(3): 788-801, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-30661255

18.

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease.

Loomba, Rohit; Kayali, Zeid; Noureddin, Mazen; Ruane, Peter; Lawitz, Eric J; Bennett, Michael; Wang, Lulu; Harting, Eliza; Tarrant, Jacqueline M; McColgan, Bryan J; Chung, Chuhan; Ray, Adrian S; Subramanian, G Mani; Myers, Robert P; Middleton, Michael S; Lai, Michelle; Charlton, Michael; Harrison, Stephen A.

Gastroenterology ; 155(5): 1463-1473.e6, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30059671

19.

Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis.

Lawitz, Eric J; Coste, Angie; Poordad, Fred; Alkhouri, Naim; Loo, Nicole; McColgan, Bryan J; Tarrant, Jacqueline M; Nguyen, Tuan; Han, Ling; Chung, Chuhan; Ray, Adrian S; McHutchison, John G; Subramanian, G Mani; Myers, Robert P; Middleton, Michael S; Sirlin, Claude; Loomba, Rohit; Nyangau, Edna; Fitch, Mark; Li, Kelvin; Hellerstein, Marc.

Clin Gastroenterol Hepatol ; 16(12): 1983-1991.e3, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-29705265

20.

Reply.

Sanyal, Arun J; Chung, Chuhan; Myers, Robert P; Bosch, Jaime.

Hepatology ; 76(1): E5-E6, 2022 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-35102590

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